As a result, it is actually conceivable which the JIP1/three???ASK1???MKK4 signaling module may well function a conduit to activate JNK when endosomal trafficking is disrupted and glucose levels tumble over the early levels of methuosis. Our locating that MKK4 was robustly activated by the methuosis-inducing IPPs, MOMIPP and 2q, and fewer so by the